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iloperidone boosts levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Iloperidone is a time-dependent CYP3A inhibitor and could bring on greater plasma amounts of drugs predominantly eradicated by CYP3A4.A variety of plausible but uninvestigated sites of action for modafinil, the two intracellular and e
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